JAK/STAT proteins and their biological impact on NK cell development and function

Publication date: Available online 28 January 2019

Source: Molecular Immunology

Author(s): Alexander Vargas-Hernández, Lisa R. Forbes

Abstract

NK cells are important early effectors in the innate immune response to a variety of viral infections and for elimination of tumor cells. The JAK/STAT signaling cascade is critical for NK cell development, maturation, survival, and proliferation, therefore, it is important to understand the role of this pathway in NK cell biology. Many cytokines can activate multiple JAK/STAT protein family members, creating a severe phenotype when mutations impair their function or expression. Here we discuss the impact of defective JAK/STAT signaling pathways on NK cell development, activation and cytotoxicity.

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