Food Protein‐Induced Enterocolitis Syndrome in South Tyrol 2012‐2016: a population based study

Abstract

Food protein‐induced enterocolitis syndrome (FPIES) is a rare non‐IgE‐mediated food allergy to protein mainly in cow milk (CM) that typically presents in early infancy. Projectile and repetitive vomiting are the main clinical symptoms after 1‐4 hours of trigger food ingestion. Rapid recognition and installment of a specific diet are important to avoid serious complications in affected children (see figure 1).¹ According to a multicenter Italian study² atopy as co‐morbidity is rarer than in other countries being 9% compared to a much higher frequency of 28% in Spain,³ 57% in Australia⁴ and over 70% in the USA.⁵ To analyze this topic further we retrospectively retrieved all clinical documents reporting FPIES, as described by Sopo et al.,² from 2012‐2016 from all pediatric services in South Tyrol, a northern Italian province near the Austrian border with 524.256 inhabitants at 2016 census.

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