Signaling pathway of globo-series glycosphingolipids and {beta}1,3-galactosyltransferase V ({beta}3GalT5) in breast cancer [Biochemistry]

The globo-series glycosphingolipids (GSLs) SSEA3, SSEA4, and Globo-H specifically expressed on cancer cells are found to correlate with tumor progression and metastasis, but the functional roles of these GSLs and the key enzyme β1,3-galactosyltransferase V (β3GalT5) that converts Gb4 to SSEA3 remain largely unclear. Here we show that the expression...

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