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Τρίτη 26 Φεβρουαρίου 2019

Solution to the 50-year-old Okazaki-fragment problem [Biochemistry]

The antiparallel structure of double-stranded DNA, together with the known 5′→3′ directionality of DNA polymerases, necessitates that the two DNA strands are replicated in opposite directions. The leading strand is synthesized in the same direction as the replication fork, whereas the lagging strand is replicated in the opposite direction. In...

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