Synergy effect of Ceftazidime-Avibactam with Meropenem against pan-resistant Acinetobacter baumannii and Serratia marcescens harboring carbapenemases: time-kill and disk approximation assays [Susceptibility]

Susceptibility of ceftazidime/avibactam and in vitro synergy with meropenem using disk approximation and time-kill assays were investigated against eleven multiresistant Acinetobacter baumannii harboring oxacillinases and five Serratia marcescens carrying bla_KPC-2. Ceftazidime/avibactam was very active and synergistic with meropenem against multiresistant S. marcescens isolates. On the other hand, only A. baumannii isolates co-harboring bla_OXA-23 and bla_OXA-117 displayed synergy. The disk approximation technique presented good sensitivity for synergism in S. marcescens.

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