T‐cell responses against 4‐tertiarybutylphenol‐exposed pigmented cells in a patient with occupational vitiligo

Abstract

Several case studies on contact/occupational vitiligo after skin contact with 4‐tertiairybutylphenol (4‐TBP) have been reported. Biochemical and cellular effects of 4‐TBP on melanocytes have been shown in vitro, but immunological analyses explaining the immunising ability of 4‐TBP leading to wide‐spread vitiligo lesions beyond areas of primary contact are still lacking. We report here the presence of a systemic T‐cell response to 4‐TBP‐exposed pigmented cells in a patient with chemically‐induced vitiligo.

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