Pulmonary wave reflections are a potential hemodynamic biomarker for pulmonary hypertension (PH) and can be analyzed using wave intensity analysis (WIA). In this study we used pulmonary vessel area and flow obtained using cardiac magnetic resonance (CMR) to implement WIA noninvasively. We hypothesized that this method could detect differences in reflections in PH patients compared with healthy controls and could also differentiate certain PH subtypes. Twenty patients with PH (35% CTEPH and 75% female) and 10 healthy controls (60% female) were recruited. Right and left pulmonary artery (LPA and RPA) flow and area curves were acquired using self-gated golden-angle, spiral, phase-contrast CMR with a 10.5-ms temporal resolution. These data were used to perform WIA on patients and controls. The presence of a proximal clot in CTEPH patients was determined from contemporaneous computed tomography/angiographic data. A backwards-traveling compression wave (BCW) was present in both LPA and RPA of all PH patients but was absent in all controls (P = 6e(-8)). The area under the BCW was associated with a sensitivity of 100% [95% confidence interval (CI) 63-100%] and specificity of 91% (95% CI 75-98%) for the presence of a clot in the proximal PAs of patients with CTEPH. In conclusion, WIA metrics were significantly different between patients and controls; in particular, the presence of an early BCW was specifically associated with PH. The magnitude of the area under the BCW showed discriminatory capacity for the presence of proximal PA clot in patients with CTEPH. We believe that these results demonstrate that WIA could be used in the noninvasive assessment of PH.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1med7wW
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
▼
2015
(1500)
-
▼
Δεκεμβρίου
(1450)
-
▼
Δεκ 11
(50)
- A new cascade halosulfonylation of 1,7-enynes towa...
- Combined treatment of somatostatin analogues with ...
- IJMS, Vol. 16, Pages 29673-29681: One-Electron Red...
- Sandwich organization of non-ionic surfactant liqu...
- Assessment of the stability of exogenous gamma hyd...
- Supporting and assisting the execution of flexible...
- Towards the understanding of variable amplitude fa...
- Noninvasive pulmonary artery wave intensity analys...
- Na-isoleren van bestaande spouwmuren: bevindingen ...
- De erkende boekhouder (-fiscalist) anno 2015, klaa...
- Non-invasive, energy-based assessment of patient-s...
- Analysis of a twin-screw granulation process using...
- Assessment of wall elasticity variations on intral...
- Development of regime map for steady-state high sh...
- The impact of modelling compression in secondary c...
- Spatio-temporal modelling of filter cake formation...
- Critical analysis of constitutive functions for hi...
- Experimental investigation linking granulation per...
- Gender op school: meer dan een jongens-meisjeskwestie
- Ecological evaluation criteria driving integrated ...
- The effects of cohabitation on family formation in...
- Towards improved accuracy in modelling aeration ef...
- Schoolmoeheid door economische deprivatie?
- Should firms outsource their basic research? The i...
- Small firm innovation performance and employee inv...
- Desmoplastic Melanoma: An Updated Immunohistochemi...
- Impact of the flocculation state on hindered and c...
- MIP loaded porous scaffolds for multi-mycotoxin an...
- Physical activity, physical fitness and screen-tim...
- MIP loaded porous scaffolds for multi-mycotoxin an...
- Multi-Component Organic Layers on Metal Substrates
- IDEMCare paper data: Transcripts of Qualitative in...
- Metabolic regulation of hepatitis B immunopatholog...
- Are cosmopolitan dispositions learned at home, at ...
- Translating Population Difference: The Use and Re-...
- Erratum to: PREVENTT: preoperative intravenous iro...
- Non-recurrent traffic congestion detection on hete...
- Navigating through digital folders uses the same b...
- The Relationship Between Apraxia of Speech and Ora...
- Comparison of Computer-Assisted Planning and Manua...
- Continuous Heterogeneously Catalyzed Oxidation of ...
- Event Networks and the Identification of Crime Pat...
- Probing extended modes on disordered plasmonic net...
- Motor imagery of hand actions: Decoding the conten...
- Experimental analysis of multistatic wind turbine ...
- High-sensitivity field emission magnetometers and ...
- The fluid dynamics of the chocolate fountain
- Statistical characterization of the growth and spa...
- No Simple Stories: Die litauisch-jüdischen Beziehu...
- Perspectives of Low-Income African-American Women ...
-
▼
Δεκ 11
(50)
-
▼
Δεκεμβρίου
(1450)
Ετικέτες
Παρασκευή 11 Δεκεμβρίου 2015
Noninvasive pulmonary artery wave intensity analysis in pulmonary hypertension
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου