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Πέμπτη 7 Ιανουαρίου 2016

Sequential Au(I)/chiral tertiary amine catalysis: a tandem C-H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles

GA?id=C5CC10096H

Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5CC10096H, Communication
Zhong-Yan Cao, Yu-Lei Zhao, Jian Zhou
We report an unprecedented sequential Au(I)/bifunctional tertiary amine catalysis, which enables a tandem C-H functionalization of weak nucleophiles (anisoles or thiophenes) and asymmetric Michael addition for the highly enantioselective synthesis of quaternary oxindoles.
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