"On-demand" release of genetic material for regulation of cell gene expression to control cell behavior is an innovative strategy for disease therapeutics and tissue regeneration. On page 305, E. Alsberg and co-workers explore a photolabile hydrogel system that can be used to actively tune the release of siRNA via the application of external UV light. The cover image illustrates how external UV light drives hydrogel degradation, and this accelerates the release of siRNA to ultimately alter gene expression of recipient cells.
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