Primary signet ring cell carcinoma of the cervix: A case report and review of the literature.

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Primary signet ring cell carcinoma of the cervix: A case report and review of the literature.

Int J Surg Case Rep. 2016 Feb 6;21:1-5

Authors: Sal V, Kahramanoglu I, Turan H, Tokgozoglu N, Bese T, Aydin O, Demirkiran F, Arvas M

Abstract
INTRODUCTION: Primary signet cell carcinoma of the cervix has been reported only in 18 cases to date.
PRESENTATION OF CASE: A 48-year-old woman was seen at our Gynecologic Oncology Unit, because she complained postcoital bleeding during the last three months. She had 1-2 cm cervical mass, originating from the endocervical canal. A biopsy revealed a signet ring cell-type adenocarcinoma. Suspected primary sites were excluded after gastroscopy, colonoscopy and mammography. The patient underwent a laparoscopic type-3 radical hysterectomy with bilateral salpingo-oophorectomy, pelvic lymph node dissection and paraaortic lymph node dissection with a presumed diagnosis of primary signet ring cell carcinoma of the cervix. Microscopically, the tumour consisted of 70% signet ring cell type and 30% endocervical adenocarcinoma. She did not receive any adjuvant treatment. Follow-up at 18 months after surgery showed no evidence of recurrence.
DISCUSSION: Nineteenth case of a primary signet ring cell carcinoma of the cervix was presented. Immunohistochemical studies and HPV DNA positivity may help in diagnosis.
CONCLUSION: It is crucial to differentiate primary tumour from metastatic signet cell carcinoma, while treatment and prognosis differ significantly.

PMID: 26874582 [PubMed - as supplied by publisher]

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