Extensive tumoral melanosis associated with ipilimumab-treated melanoma

Abstract

Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but that histologically reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumor. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique case of extensive tumoral melanosis arising during ipilimumab treatment of in-transit metastases from a previously excised melanoma.

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