Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection

Abstract

Background

Members of triggering receptor expressed on myeloid cells (TREM) family are known as immunmodulators in several infectious or noninfectious inflammatory disorders. The information about their role in viral infections is very limited. To enlighten if there's a relation between soluble TREM-1(sTREM-1) and a viral infection, Crimean Congo Haemorrhagic Fever (CCHF).

Methods

We investigated the levels of sTREM-1 in the sera of 39 CCHF patients both at admission and at recovery and compared with 40 healthy controls by using microELISA technique. Statistical analysis was made by using Statistical Package for Social Sciences (SPSS) for Windows 20 programme. Value of p < 0.05 was accepted as significant for statistical analyses.

Results

Median sTREM-1 level was higher in CCHF group when compared to the control group (1961 pg/mL vs 151.1 pg/mL, respectively; p < 0.001). In CCHF patients, sTREM-1 levels were significantly decreased at recovery compared to initial level measured at hospital admission (1961 pg/mL vs 948 pg/mL, respectively; p = 0.019). ▵sTREM-1 is correlated with ▵CRP, ▵WBC and ▵Plt. We found that serum levels of sTREM-1 higher than 405.9 pgm/L existed as a cut off point for differentiating CCHF patients and control group with a sensitivity of 94.9% and specifity of 87.5%.

Conclusions

It is proved that sTREM-1 is increased and correlates with the clinical and laboratory findings in CCHF, a viral infection characterised by activation of inflammation. This finding may lead new studies to enlighten the pathogenesis of infections developing by activation of inflammatory cascades and high level cytokine releases, especially. This article is protected by copyright. All rights reserved

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