Rapid T2 mapping of mouse heart using the carr–purcell–meiboom–gill sequence and compressed sensing reconstruction

Purpose

To develop and prove preliminary validation of a fast in vivo T₂ mapping technique for mouse heart.

Materials and Methods

Magnetic resonance imaging (MRI) experiments were performed on a 7T animal scanner. The standard Carr–Purcell–Meiboom–Gill (CPMG) sequence was modified to minimize the effect of stimulated echoes for accurate T₂ quantification. The acquisition was further accelerated with the compressed sensing approach. The accuracy of the proposed method was first validated with both phantom experiments and numerical simulations. In vivo T₂ measurement was performed on seven mice in a manganese-enhanced MRI study.

Results

In phantom studies, T₂ values obtained with the modified CPMG sequence are in good agreement with the standard spin-echo method (P > 0.05). Numerical simulations further demonstrated that with the application of the compressed sensing approach, fast T₂ quantification with a spatial resolution of 2.3 mm can be achieved at a high temporal resolution of 1 minute per slice. With the proposed technique, an average T₂ value of 25 msec was observed for mouse heart at 7T and this number decreased significantly after manganese infusion (P < 0.001).

Conclusion

A rapid T₂ mapping technique was developed and assessed, which allows accurate T₂ quantification of mouse heart at a temporal resolution of 1 minute per slice. J. Magn. Reson. Imaging 2016.

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