FGFR1 N546K and H3F3A K27M mutation in a diffuse leptomeningeal tumor with glial and neuronal markers

Abstract

Glioneuronal tumors (GNTs) are rare central nervous system neoplasms characterized by glial and neuronal markers that typically follow an indolent clinical course (1, 2). Several subgroups of GNTs are currently recognized by the World Health Organization (WHO) including papillary GNT, rosette-forming GNTs of the fourth ventricle, and rosetted GNTs with neuropil-like islands; however a new subset of diffuse leptomeningeal GNTs (DL-GNTs) has been proposed (1-3). While the exact clinical features of diffuse leptomeningeal GNT (DL-GNT) remain controversial, potential defining characteristics include the presence of multiple small cysts/nodules, and lack of an intraparenchymal mass (1).

This article is protected by copyright. All rights reserved.

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/22k0vlL
via IFTTT