Evaluation of the Ability of a Novel Miconazole Formulation to Penetrate Nail Using Three Nail In Vitro Models [PublishAheadOfPrint]

In an effort to increase the efficacy of topical medications to treat onychomycosis, several new nail penetration enhancers have recently been developed. In this study, the ability of 10% w/w miconazole nitrate, combined with a penetration enhancer formulation to permeate the nail, is demonstrated by the use of a selection of in vitro nail penetration assays. These assays include bovine hoof, TurChub® zone of inhibition, and infected nail models.

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