The Correlation between gyrA and CmeR-Box Polymorphism and Fluoroquinolones Resistance in Campylobacter jejuni Isolates in China [PublishAheadOfPrint]

Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations were identified, including point substitutions, deletion and insertion. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increase the expression of cmeABC and contribute to the high fluoroquinolone resistance.

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