New macrolide-lincosamide-streptogramin B resistance gene erm(48) on the novel plasmid pJW2311 in Staphylococcus xylosus [PublishAheadOfPrint]

Whole-genome sequencing of Staphylococcus xylosus strain JW2311 from bovine mastitis milk identified the novel 49.3 kb macrolide-lincosamide-streptogramin B (MLS_B) resistance plasmid pJW2311. It contained the macrolide resistance gene mph(C), the macrolide-streptogramin B resistance gene msr(A), and the new MLS_B resistance gene erm (48) and could be transformed into S. aureus by electroporation. Functionality of erm (48) was demonstrated by cloning and expression in S. aureus.

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