Nickel-catalyzed amination of aryl carbamates with ammonia

Aryl carbamates were employed in the nickel-catalyzed monoarylation of ammonia. The applied, well-defined, singlecomponent nickel(II) precatalyst contains a Josiphos ligand, is air-stable and operates without any ancillary reductant. This catalyst system also promotes the amination of aryl carbamates with ammonium sulfate as well as hydrochloride salts of primary alkyl amines. Their easy preparation, robustness, and directing group ability makes aryl carbamates particularly attractive synthetic intermediates.

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2qjTeK8
via IFTTT