First report of Klebsiella oxytoca strain simultaneously producing NDM-1, IMP-4 and KPC-2 carbapenemases [PublishAheadOfPrint]

The nucleotide sequences of 5 plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that bla_NDM-1 was carried on an IncX3 plasmid. The bla_IMP-4 and bla_KPC-2 were located on an IncN and an IncP-6 plasmid, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harbouring plasmids among different enterobacterial species. It reports for the first time coproducing NDM-1, KPC-2 and IMP-4 carbapenemases on a K. oxytoca isolate.

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