In Vitro Activity of Ceftolozane-Tazobactam and Other Antimicrobial Agents Against Burkholderia cepacia Complex and Burkholderia gladioli [PublishAheadOfPrint]

We tested the activity of ceftolozane-tazobactam and 13 other antimicrobial agents against 221 strains of Burkholderia cepacia complex and Burkholderia gladioli. Most strains (82%) were cultured from persons with cystic fibrosis, and most (85%) were recovered since 2011. The ceftolozane-tazobactam MIC was ≤ 8 μg/ml for 77% of the strains. However, the MIC range was broad (≤0.5 to >64 μg/ml; MIC_50/90, 2/32 μg/ml). Significant differences in susceptibility to some antimicrobial agents were observed between species.

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