In Vitro Antibiotic Susceptibilities of Francisella tularensis by Broth Micro-Dilution Following CLSI Methods. [PublishAheadOfPrint]

In vitro susceptibilities for 47 antibiotics were determined in 30 genetic diverse strains of Francisella tularensis by the broth micro-dilution method following Clinical Laboratory Standards Institute (CLSI) methods. The F. tularensis strains demonstrated susceptibility to aminoglycosides, fluoroquinolones and tetracyclines. There was a distinct difference in macrolide susceptibility between "A" and "B" type strains as has been noted previously. Establishing and comparing antibiotic susceptibilities of a diverse but specific set of F. tularensis strains by standardized methods and establishment of population ranges and MIC_50/90 values provides reference information for assessing new antibiotic agents, and provides a baseline to monitor any future emergence of resistance, natural or intentional.

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