Burden of chronic urticaria relative to psoriasis in five European countries

Abstract

Background

Quantification of burden of chronic spontaneous urticaria (CSU) versus psoriasis (PsO) is limited.

Objective

To evaluate the burden associated with CSU versus PsO of all severities (overall PsO), mild and moderate/severe PsO.

Methods

his retrospective cross-sectional analysis compared data from adult patients with chronic urticaria (CU), used as a proxy for CSU, and PsO from the National Health and Wellness Survey in France, Germany, Italy, Spain, and the United Kingdom. Outcomes included mental and physical component summary scores (MCS and PCS) calculated from the Short-Form (SF)-36v2 or SF-12v2, SF-6D health utility scores, self-reported psychological complaints (anxiety, depression, and sleep difficulties), work productivity and activity impairment, and self-reported health care resource utilisation. Bivariate and multivariate analyses for each outcome and comparative group were conducted.

Results

This analysis included 769 CU and 7857 PsO (26.9% moderate/severe) patients. Following adjustment for covariates, CU patients showed a greater health-related quality of life (HRQoL) impairment versus overall PsO (MCS:-2.4, PCS:-1.6, SF-6D:-0.03; all p< 0.001). CU patients showed a higher risk of anxiety, depression, and sleep difficulties (odds ratio [OR]: 1.63, 1.34, and 1.56, respectively; all P< 0.01) and greater healthcare resource use versus overall PsO. The overall activity impairment was significantly greater in CU patients than in overall PsO patients (P=0.001) while the impact on work was not-significantly different. The results vs. moderate/severe PsO group showed no significant differences on all outcomes.

Conclusion

Burden of illness in CU is higher than PsO of all severities but similar to that observed in moderate/severe PsO. Both diseases have a similar negative impact on work productivity.

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