Compulsive sexual behaviour in Parkinsons disease is associated with higher doses of levodopa

Introduction

Previous research estimates the lifetime prevalence of compulsive sexual behaviour (CSB) in individuals with Parkinson's disease (PD) to be 2.7%. CSB has also been associated with male gender and earlier onset of PD.1 Although both dopamine agonists (DAs) and, to a lesser extent, levodopa have been associated with impulsive compulsive behaviours (ICBs),2 it is still unclear whether higher levodopa doses are a risk factor for the development of CSB in patients with PD.

Methods

Patients with ICBs were identified from a database of individuals with PD and ICBs who were seen at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, and who had participated in three previous research projects over an 8-year period (from 2008 to 2016). All the ICB cases were recruited to research studies from PD clinics at the National Hospital and selected due to the reporting of ICBs. All cases underwent a...

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