Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica

Abstract

We report a case of chromoblastomycosis due to presence of large plaque and verrucous hyperplasia lesions on the left upper limb, with elbow abnormal activities, in a 56-year-old male. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. Molecular tools were applied to identifying the causative agent: Fonsecaea nubica, which is rarely reported to be associated with chromoblastomycosis. The patient was initially treated orally with terbinafine (250 mg/day) and itraconazole (200 mg/day), subsequently patient received thermotherapy (45-50 °C, 3 hours/day) for one month. The patient was successfully cured. A literature review was performed to assess general features, treatment and outcome of chromoblastomycosis due to Fonsecaea nubica. All the five reviewed patients were male, over 30-years-old, and their lesions were occurred after traumatic inoculation.

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