Increased resting-state brain entropy in Alzheimer’s disease

Entropy analysis of resting-state functional MRI (R-fMRI) is a novel approach to characterize brain temporal dynamics and facilitates the identification of abnormal brain activity caused by several disease conditions. However, Alzheimer's disease (AD)-related brain entropy mapping based on R-fMRI has not been assessed. Here, we measured the sample entropy and voxel-wise connectivity of the network degree centrality (DC) of the intrinsic brain activity acquired by R-fMRI in 26 patients with AD and 26 healthy controls. Compared with the controls, AD patients showed increased entropy in the middle temporal gyrus and the precentral gyrus and also showed decreased DC in the precuneus. Moreover, the magnitude of the negative correlation between local brain activity (entropy) and network connectivity (DC) was increased in AD patients in comparison with healthy controls. These findings provide new evidence on AD-related brain entropy alterations. Correspondence to Shao-Wei Xue, PhD, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China, Room 301, Shuyuan Building No. 19, Yuhangtang Road No. 2318, Hangzhou 311121, Zhejiang Province, China Tel: +86 152 5715 2036; fax: +86 571 2886 7717; e-mail: xuedrm@126.com Received October 16, 2017 Accepted November 2, 2017 © 2017 Wolters Kluwer Health | Lippincott Williams & Wilkins

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2AScku4
via IFTTT