FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes [Immunology and Inflammation]

FoxP3+ regulatory T cells (Tregs) are a central element of immunological tolerance. FoxP3 is the key determining transcription factor of the Treg lineage, interacting with numerous cofactors and transcriptional targets to determine the many facets of Treg function. Its absence leads to devastating lymphoproliferation and autoimmunity in scurfy mutant mice...

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