Omadacycline was tested against 125 isolates recovered from infected cat and dog bites in humans. Its activity was similar to other compounds in the tetracycline class and was active against strains exhibiting tetracycline resistance. Against anaerobic isolates, resistance to tetracyclines was more prominent, and omadacycline was the most active of the group. All isolates had omadacycline MICs <1 μg/ml with the exception of Eikenella corrodens which showed reduced susceptibility to the entire tetracycline group.
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