The In Vitro Activity of Omadacycline and Comparators Against Anaerobic Bacteria [PublishAheadOfPrint]

Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically-relevant anaerobes was similar to tigecycline, with MIC₉₀ values of 1 to 8 μg/mL against Bacteroides spp, 0.5 μg/mL against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica, 1 μg/mL against Peptostreptoccus spp., and 16 μg/mL against C. perfringens.

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