Recent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute diarrhea caused by Cryptosporidium hominis, the species responsible for most human cases. Five day-treatment with BKI 1369 reduced signs of disease early during treatment compared with untreated animals. Piglets treated with BKI 1369 exhibited a significant reduction of oocyst excretion, mucosal colonization by C. hominis, and mucosal lesions, which resulted in considerable symptomatic improvement. BKI 1369 reduced parasite burden and disease severity in the gnotobiotic pig model. Together, these data suggest that the BKI-mediated therapeutic could potentially be an effective treatment against cryptosporidiosis.
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