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Τρίτη 10 Ιουλίου 2018

Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA [Chemistry]

DNA-encoded libraries (DEL)-based discovery platforms have recently been widely adopted in the pharmaceutical industry, mainly due to their powerful diversity and incredible number of molecules. In the two decades since their disclosure, great strides have been made to expand the toolbox of reaction modes that are compatible with the idiosyncratic...

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