Effect of institutional case volume on in-hospital mortality after living donor liver transplantation: Analysis of 7073 cases between 2007 and 2016 in Korea

Background The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified. Methods We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 adult living donor liver transplantations were performed at 50 centers in Korea. Centers were categorized according to the average annual number of liver transplantations: >50, 10 to 50, and 50 liver transplantations/year) had better outcomes after living donor liver transplantation, including in-hospital mortality and long-term mortality, compared to centers with lower case volume (≤50 liver transplantations/year). Seokha Yoo and Eun Jin Jang contributed equally to this work and are co-first authors. Corresponding author: Ho Geol Ryu, MD, PhD, Seoul National University Hospital, Seoul National University College of Medicine, Daehak-ro 101, Jongno-gu, Seoul, 03080, Republic of Korea, E-mail: hogeol@gmail.com Authorship S.Y.: Study design, Data analysis, First draft of manuscript E.J.J.: Data acquisition, Data analysis, First draft of manuscript N.J.Y.: Revision of manuscript G.H.K.: Data acquisition, Data analysis D.H.K.: Data acquisition, Data analysis H.L.: Study conception, Revision of manuscript C.W.J.: Study design, Revision of manuscript H.G.R.: Study conception, Study design, Revision of manuscript Disclosure The authors declare no conflicts of interest. Funding None. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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