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Τρίτη 7 Αυγούστου 2018

Elesclomol restores mitochondrial function in genetic models of copper deficiency [Biochemistry]

Copper is an essential cofactor of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Inherited loss-of-function mutations in several genes encoding proteins required for copper delivery to CcO result in diminished CcO activity and severe pathologic conditions in affected infants. Copper supplementation restores CcO function in...

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