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Τρίτη 23 Οκτωβρίου 2018

Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119 [Biophysics and Computational Biology]

The enhanced thermostability of thermophilic proteins with respect to their mesophilic counterparts is often attributed to the enthalpy effect, arising from strong interactions between protein residues. Intuitively, these strong interresidue interactions will rigidify the biomolecules. However, the present work utilizing neutron scattering and solution NMR spectroscopy measurements demonstrates a contrary...

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