Eukaryotic Rad51 protein is essential for homologous-recombination repair of DNA double-strand breaks. Rad51 recombinases first assemble onto single-stranded DNA to form a nucleoprotein filament, required for function in homology pairing and strand exchange. This filament assembly is the first regulation step in homologous recombination. Rad51 nucleation is kinetically slow, and...
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Τρίτη 23 Οκτωβρίου 2018
Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation [Biophysics and Computational Biology]
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