Population pharmacokinetics with Monte Carlo simulations of gentamicin in an adult severely ill sub-Saharan African patient population [Pharmacology]

In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-ICU settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population (n=48) treated with gentamicin and developed a pharmacokinetic model using non-linear mixed effect modeling. Simulations showed that non-ICU SSA patient populations may be at substantial risk for underexposure to gentamicin during routine once-daily dosing.

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