Susceptibility of mecillinam in Enterobacterales - results from a prospective in vitro study [Susceptibility]

The activity of mecillinam was assessed in Enterobacterales (n=420) isolated from urines in 2016/2017. Mecillinam susceptibility was 97.4% in E. coli (294/302), 89.7% in Klebsiella spp. (52/58) and 93.3 % in Proteus mirabilis (28/30). Among ESBL producers 95.2% (99/104) were mecillinam susceptible, including two OXA-48-producing K. pneumoniae. In Enterobacter spp. and Citrobacter spp., minimal inhibitory concentration were low (MIC₅₀=0.5 mg/L). In conclusion, the activity of mecillinam was high in Enterobacterales, even among multidrug-resistant isolates.

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