Association analysis within MHC region of psoriasis vulgaris accounting for familial history

Abstract

Psoriasis vulgaris (PsV) is the most common subtype of psoriasis which only involved the skin and without joint symptoms, and both environmental and genetic factors were involved in its etiology ¹. Some patients have familial genetic predisposition, more than 80 susceptibility genes/loci have been identified². Human leukocyte antigen system (HLA) has been identified to be significantly associated with psoriasis and explained vital part of the genetic factors in pathogenesis of psoriasis³.

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