Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness

Drug induced enterocolitis syndrome (DIES) is a rare, non-IgE mediated hypersensitivity reaction provoked by drugs which can be severe and lead to shock. Despite the potential severity of the reactions, awareness of DIES is low. In contrast, enterocolitis syndrome induced by food proteins (FPIES) has been better documented. Previous studies have reported the occurrence of hypovolemic shock in approximately 15% of reactions, which indicates that FPIES is a potentially life threating disease.(1) To increase clinical awareness on DIES we here report a case of a child who was referred to our pediatric allergy clinic and was diagnosed with DIES by amoxicillin.

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