Contributors : Qiling He ; C S Swindle ; Chao Wan ; Robert J Flynn ; Dongquan Chen ; Christopher A KlugSeries Type : Expression profiling by arrayOrganism : Mus musculusMultiple hypothesis testing using a false discovery rate of p
8h
Series Type : OtherOrganism : Homo sapiensMyelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematological disorders characterized by the presence of peripheral cytopenias and an increased risk of transformation into acute myeloblastic leukemia (AML). These hematological disorders are complex and their origin in a clonal hematopoietic stem cell disorder is accepted. In the last few years, the importance of the bone marrow (BM) microenvironment has been highlighted. Bone marrow...
8h
Contributors : Eraj S Khokhar ; Sneha Borikar ; Elizabeth Eudy ; Tim Stearns ; Kira Young ; Jennifer J TrowbridgeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Gene expression profiling of long term hematopoietic stem cells (LT-HSCs) transduced with Kat6b shRNA and Non-Targeting Control (NTC)
8h
Contributors : Anna Sliz ; Kasper HoebeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe study compares RNAseq expression in gd8.5 uNK cells isolated from the placentas from WT C57BL/6J and Gab3-KO pregnant females.
8h
Contributors : Matthew Ginley-Hidinger ; Jason GertzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMultiple regulatory regions bound by the same transcription factor have been shown to simultaneously control a single gene’s expression. However, it remains unclear how these regulatory regions combine to regulate transcription. Here we test the sufficiency of promoter-distal estrogen receptor α (ER)-binding sites (ERBS) for activating gene expression...
8h
Contributors : Heng Xu ; Hao Zhang ; Cheng Luo ; Xu-Wen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTwo novel polyketides, ocellatusones A and B (1 and 2), characterized by either an uncommon oxatricyclo[4.2.1.02,4]nonane skeleton (1) or a mesitylene connected dimethylfuran-3(2H)-one nucleus (2), were isolated in racemic forms from the South China Sea sacoglossan Placobranchus ocellatus, together with seven uncommon polypropionates (3, 4a,4d, 5, and...
8h
Series Type : Expression profiling by arrayOrganism : Homo sapiensGene expression profiling reveals a potential role of rosmarinic acid in neural induction and neuronal differentiation of hAECs.hAECs were isolated from discarded term placenta and were treated with 20 μM RA for seven days. Microarray gene expression profiling was conducted for biological replicates of RA-treated (T7) and untreated control cells on day 0 (D0) and day 7 (D7).
8h
Contributors : Yasumasa Kanai ; Akiko Katsumata ; Yoko Ono ; Toshio OtaSeries Type : Expression profiling by arrayOrganism : Mus musculusObjective The risk of ulcerative colitis (UC)-associated colorectal cancer (CRC) increases with the duration of UC. Oral 5-aminosalicylic acid (5-ASA) formulations are the first-line treatment for mild-to-moderate UC; nevertheless, preventive effect of oral 5-aminosalicylic acid (5-ASA) formulations on UC-associated CRC remains unsolved. We investigated the...
8h
Contributors : Ethan Lippmann ; Brian McIntosh ; Mitchell D Probasco ; Peng Jiang ; Scott Swanson ; Ron M Stewart ; James A Thomson ; Randolph S AshtonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe generated RNA-seq data to measure transcriptional profiles of twenty hPSC-derived NSC populations, representing distinct regions of the developing human hindbrain and rostral cervical spinal cord. These cells are differentiated using a protocol that induces...
14h
Contributors : Hani Nakhoul ; Zhen Lin ; Xia Wang ; Claire Roberts ; Yan Dong ; Erik FlemingtonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCertain peripheral T-cell lymphomas (PTCLs) have been associated with viral infection, particularly infection with Epstein-Barr virus (EBV). However, a comprehensive virome analysis across PTCLs has not previously been reported, and viral gene expression profiles have been studied only in certain PTCL subtypes....
15h
Contributors : Christian K Dye ; Michael J Corley ; Razvan Sultana ; Alika K MaunakeaSeries Type : Methylation profiling by arrayOrganism : Homo sapiensGenome wide DNA methylation profiling of monocytes from insulin sensitive and insulin resistant HIV-infected patients. The Illumina Infinium Human Methylation 450k Beadchip was used to obtain DNA methylation profiling across 450,000+ CpGs. Samples included monocytes from 37 HIV-infected individuals, of which 14 were insulin resistant and 23 were...
16h
Contributor : Scott RyanSeries Type : Expression profiling by arrayOrganism : Homo sapiensA53T mutant human DA neurons or their isogenic control counterparts were differentiated to DA-Neurons for 35 days. Gene expression profile was analysed to assess the effect of the genetype on gene expression.
17h
Contributors : Hans W Snoeck ; Alexandros StrikoudisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntroduction of Hermansky-Pudlak Syndrome-associated mutations with CRISPR/Cas9 genome editing, allows for disease modeling in 3D cultures of hPSC-derived lung organoids.
18h
Contributors : Consuelo Lomas-Soria ; Peter W Nathanielsz ; Laura A Cox ; Elena ZambranoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusMaternal high-fat diet consumption predisposes to metabolic and liver dysfunction in F1 male and female at young adulthood.Purpose: We used RNA-seq to determine the liver transcriptome of male and female F1 of MO and control fed mothers.Methods: Female Wistar rat mothers ate control (C) or obesogenic (MO) diet from the...
18h
Contributors : R Inoue ; R TamakiSeries Type : Expression profiling by arrayOrganism : Homo sapiensWhole blood was collected from healthy adult and peripheral blood mononuclear cells (PBMC) were isolated. PBMCs were cultured in medium or stimulated with RNase treated EC-12 or untreated EC-12 for 6hours. Then transcriptome profiles in PBMC were obtained.
18h
Contributors : Ali Jabbari ; Nicholas BorcherdingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCutaneous T cell lymphomas (CTCL), encompassing a spectrum of T-cell lymphoproliferative disorders involving the skin, have collectively increased in incidence over the last 40 years. Sézary syndrome (SS) is an aggressive form of CTCL characterized by significant presence of malignant cells in both the blood and skin. The guarded prognosis for SS reflects a lack...
18h
Contributors : H Nagashima ; H Y Shih ; H W Sun ; S R Brooks ; G Gutierrez-Cruz ; S Dell'Orso ; Y Kanno ; J J O'SheaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusInnate and adaptive lymphocytes work in concert to maintain tissue homeostasis and to mediate host defense at mucosal barriers. Herein, we used single cell analysis to show substantial diversity of gene expression in ILCs and T...
18h
Contributors : Ergun Sahin ; Hisayuki AmanoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusWe have characterized the p53-dependent miRNAs in murine liver in telomerase knckout mice with short telomeres
18h
Contributors : Sarah Pedretti ; Marie-Claude Brulhart-Meynet ; Fabrizio Montecucco ; Sandrine Lecour ; Richard W James ; Miguel A FriasSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculus ; synthetic constructWe investigated whether the cardioprotective effect of HDL modulates miRNAs as a downstream target of STAT3 activation.
18h
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