Contributors : Joe Rainger ; James G PrendergastSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusOcular tissue RNAseq from WT embryos
19h
Contributors : Uwe Rix ; Natalia J Sumi ; Steven A EschrichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite recent improvements many cancer patients do not respond to immune or targeted drugs and require new therapies. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the mechanism of action underlying the differential anticancer activity of two structurally related multi-kinase...
20h
Contributors : Colin Wu ; Rachel GreenSeries Type : OtherOrganism : Saccharomyces cerevisiaeRibosome stalling at problematic sequences in mRNAs leads to collisions that trigger a collection of quality control events including ribosome rescue, targeting the nascent polypeptide for decay (Ribosome-mediated Quality Control or RQC), and targeting of the mRNA for decay (No Go Decay or NGD). Using a reverse genetic screen in yeast, we identify Cue2 as the endonuclease that is recruited to stalled ribosomes...
21h
Contributor : Soojin V YiSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensWe carried out cell-type specific whole genome bisulfite sequencing from BA46 that underwent fluorescence-activated nuclei sorting (FANS).
21h
Contributor : Soojin V YiSeries Type : OtherOrganism : Homo sapiensWe carried out whole genome sequencing of 29 schizophrenia patients and 25 control individuals
21h
Contributors : Stefano Berto ; Noriyoshi Usui ; Kazuya Toriumi ; Connor Douglas ; Genevieve KonopkaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo address the heterogeneity of gene regulation and expression in cell types of a brain region with strong evidence for relevance to schizophrenia, we carried out whole genome methylation and expression analyses using post-mortem brain tissue from BA46 that underwent fluorescence-activated nuclei sorting (FANS)....
21h
Contributors : Simon Lalonde ; Valérie-Anne Codina-Fauteux ; Sébastian Méric de Bellefon ; Francis Leblanc ; Mélissa Beaudoin ; Rola Dali ; Tony Kwan ; Ken Sin Lo ; Tomi Pastinen ; Guillaume LettreSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide association studies (GWAS) have identified 100s of loci associated with coronary artery disease (CAD) and blood pressure (BP)/hypertension. Many of these loci are not associated with...
22h
Contributors : Simon Lalonde ; Valérie-Anne Codina-Fauteux ; Sébastian Méric de Bellefon ; Francis Leblanc ; Mélissa Beaudoin ; Rola Dali ; Tony Kwan ; Ken Sin Lo ; Tomi Pastinen ; Guillaume LettreSeries Type : OtherOrganism : Homo sapiensGenome-wide association studies (GWAS) have identified 100s of loci associated with coronary artery disease (CAD) and blood pressure (BP)/hypertension. Many of these loci are not associated with traditional risk factors, nor include obvious candidate genes,...
22h
Contributors : Salix Boulet ; Nathalie LabrecqueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe molecular requirements that guide the differentiation of monocytes into macrophages or monocyte-derived dendritic cells (Mo-DCs) are poorly understood. Here, we demonstrate that the nuclear orphan receptor NR4A3 guides monocyte fate and is essential for Mo-DC differentiation. Nr4a3-/- mice are impaired in the in vivo generation of DC-SIGN+ Mo-DCs following LPS...
22h
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
22h
Contributors : Simon Lalonde ; Valérie-Anne Codina-Fauteux ; Sébastian Méric de Bellefon ; Francis Leblanc ; Mélissa Beaudoin ; Rola Dali ; Tony Kwan ; Ken Sin Lo ; Tomi Pastinen ; Guillaume LettreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide association studies (GWAS) have identified 100s of loci associated with coronary artery disease (CAD) and blood pressure (BP)/hypertension. Many of these loci are not associated with traditional...
22h
Contributors : Simon Lalonde ; Valérie-Anne Codina-Fauteux ; Sébastian Méric de Bellefon ; Francis Leblanc ; Mélissa Beaudoin ; Rola Dali ; Tony Kwan ; Ken Sin Lo ; Tomi Pastinen ; Guillaume LettreSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide association studies (GWAS) have identified 100s of loci associated with coronary artery disease (CAD) and blood pressure (BP)/hypertension. Many of these loci are not associated with...
22h
Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
23h
Contributors : Carolina Navas ; Osvaldo Graña ; Carmen GuerraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing data of AdGFP cell from mouse PDAC
1d
Contributors : Paolo Malatesta ; Irene AppolloniSeries Type : Expression profiling by arrayOrganism : Mus musculusThe trascription profiles of PDGF-B and EGFRvIII induced glioma models were compared. We show that both models converge towards a phenotype that resembles proneural glioblastoma subset.
1d
Contributors : Basuthkar J RAO ; Ishita S MEHTASeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate genome-wide transcriptomic changes during CT relocation, we have employed whole genome microarray expression profiling as a discovery platform to identify differential gene expression changes aportioned per chromosome, which were associated during an induced and controlled DNA damage response paradigm.
1d
Contributors : Masataka Hirasaki ; Yutaka Nakachi ; Yosuke Mizuno ; Yasushi Okazaki ; Akihiko OkudaSeries Type : Expression profiling by arrayOrganism : Mus musculusWe explored the effect of knockout of Mbd3 gene on global expression profile in ESCs and compared the ability to counteract such alteration among three isoforms of MBD3, i.e. MBD3a, b and c.
1d
Contributors : Hirasaki Masataka ; Akihiko Okuda ; Norihiro KotaniSeries Type : Expression profiling by arrayOrganism : Mus musculusAs a first step for identifying hypothetical splenic stem cells for nonhematopoietic cells, densely-packed colony-forming cells were isolated from mouse spleen. Those which we designated as Splenic Adherent Colony-Forming Cells (SACCs) are positive for some of stem cell markers such as alkaline phosphatase and SSEA-1 antigen. We herewith determined global expression...
1d
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