IJMS, Vol. 21, Pages 6163: Frame Coating of Single-Walled Carbon Nanotubes in Collagen on PET Fibers for Artificial Joint Ligaments International Journal of Molecular Sciences doi: 10.3390/ijms21176163 Authors: Alexander Yu. Gerasimenko Natalia N. Zhurbina Nadezhda G. Cherepanova Anna E. Semak Vadim V. Zar Yulia O. Fedorova Elena M. Eganova Alexander A. Pavlov Dmitry V. Telyshev Sergey V. Selishchev Olga E. Glukhova The coating formation technique for artificial...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6169: Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements International Journal of Molecular Sciences doi: 10.3390/ijms21176169 Authors: Nataliya R. Rovnyagina Gleb S. Budylin Yuri G. Vainer Tatiana N. Tikhonova Sergey L. Vasin Alexander A. Yakovlev Victor O. Kompanets Sergey V. Chekalin Alexander V. Priezzhev...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6166: Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21176166 Authors: Joao V. de Souza Francesc Sabanés Zariquiey Agnieszka K. Bronowska Intrinsically disordered proteins (IDPs) are molecules without a fixed tertiary structure, exerting crucial roles in cellular signalling, growth and molecular recognition events. Due...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6165: Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology International Journal of Molecular Sciences doi: 10.3390/ijms21176165 Authors: Patricia Guerrero-Ochoa Diederich Aguilar-Machado Raquel Ibáñez-Pérez Javier Macías-León Ramón Hurtado-Guerrero Javier Raso Alberto Anel Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6168: The Glycine- and Proline-Rich Protein AtGPRP3 Negatively Regulates Plant Growth in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21176168 Authors: Xiaojing Liu Xin Wang Xin Yan Shaobo Li Hui Peng Glycine- and proline-rich proteins (GPRPs) comprise a small conserved family that is widely distributed in the plant kingdom. GPRPs are relatively short peptides (<200 amino acids) that contain three typical domains, including...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6162: Ameliorated Autoimmune Arthritis and Impaired B Cell Receptor-Mediated Ca2+ Influx in Nkx2-3 Knock-out Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176162 Authors: Esam Khanfar Katalin Olasz Fanni Gábris Erzsébet Gajdócsi Bálint Botz Tamás Kiss Réka Kugyelka Tímea Berki Péter Balogh Ferenc Boldizsár B cells play a crucial role in the pathogenesis of rheumatoid arthritis. In Nkx2-3-deficient mice (Nkx2-3−/−)...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6161: Heart Failure Disturbs Gut–Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite International Journal of Molecular Sciences doi: 10.3390/ijms21176161 Authors: Drapala Szudzik Chabowski Mogilnicka Jaworska Kraszewska Samborowska Ufnal Trimethylamine (TMA) is a gut bacteria product oxidized by the liver to trimethylamine-N-oxide (TMAO). Clinical evidence suggests that cardiovascular disease is associated...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6159: Bcl-2 Overexpression and Hypoxia Synergistically Enhance Angiogenic Properties of Dental Pulp Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176159 Authors: Waruna L. Dissanayaka Yuanyuan Han Lili Zhang Ting Zou Chengfei Zhang Post-implantation cell survival and angio-/vasculogenesis are critical for the success of cell-based regenerative strategies. The current study aimed to overexpress B-cell lymphoma 2 (Bcl-2) gene...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6160: Intramolecular Hydrogen Bond Driven Conformational Selectivity of Coumarin Derivatives of Resorcin[4]arene International Journal of Molecular Sciences doi: 10.3390/ijms21176160 Authors: Anna Szafraniec Waldemar Iwanek In this study, the synthesis and structure of 4-aminocoumarin derivatives of resorcin[4]arene were investigated. Spectroscopic analysis and quantum mechanical calculations showed that this molecule undertakes a crown-in conformation in chloroform....
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6164: Metabolic Engineering of The Native Monoterpene Pathway in Spearmint for Production of Heterologous Monoterpenes Reveals Complex Metabolism and Pathway Interactions International Journal of Molecular Sciences doi: 10.3390/ijms21176164 Authors: Chunhong Li Sreelatha Sarangapani Qian Wang Kumar Nadimuthu Rajani Sarojam Spearmint produces and stores large amounts of monoterpenes, mainly limonene and carvone, in glandular trichomes and is the major...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6158: A De novo Peptide from a High Throughput Peptide Library Blocks Myosin A -MTIP Complex Formation in Plasmodium falciparum International Journal of Molecular Sciences doi: 10.3390/ijms21176158 Authors: Zill e Anam Nishant Joshi Sakshi Gupta Preeti Yadav Ayushi Chaurasiya Amandeep Kaur Kahlon Shikha Kaushik Manoj Munde Anand Ranganathan Shailja Singh Apicomplexan parasites, through their motor machinery, produce the required propulsive...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6157: Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium International Journal of Molecular Sciences doi: 10.3390/ijms21176157 Authors: Changrim Lee Maria C. Edman Gordon W. Laurie Sarah F. Hamm-Alvarez J. Andrew MacKay Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6156: Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How International Journal of Molecular Sciences doi: 10.3390/ijms21176156 Authors: Stefan Bröer Amino acids are indispensable for the growth of cancer cells. This includes essential amino acids, the carbon skeleton of which cannot be synthesized, and conditionally essential amino acids, for which the metabolic demands exceed the capacity to synthesize them. Moreover, amino acids are...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6155: Environmental Signal-Dependent Regulation of Flowering Time in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21176155 Authors: Jae Sung Shim Geupil Jang The transition from the vegetative to the reproductive stage of growth is a critical event in the lifecycle of a plant and is required for the plant’s reproductive success. Flowering time is tightly regulated by an internal time-keeping system and external light conditions,...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6149: Zinc Deficiency Disturbs Mucin Expression, O-Glycosylation and Secretion by Intestinal Goblet Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176149 Authors: Maria Maares Claudia Keil Sophia Straubing Catherine Robbe-Masselot Hajo Haase Approximately 1 billion people worldwide suffer from zinc deficiency, with severe consequences for their well-being, such as critically impaired intestinal health. In addition to an extreme degeneration...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6154: Effect of Gelation Temperature on the Molecular Structure and Physicochemical Properties of the Curdlan Matrix: Spectroscopic and Microscopic Analyses International Journal of Molecular Sciences doi: 10.3390/ijms21176154 Authors: Barbara Gieroba Anna Sroka-Bartnicka Paulina Kazimierczak Grzegorz Kalisz Izabela S. Pieta Robert Nowakowski Marcin Pisarek Agata Przekora In order to determine the effect of different gelation temperatures (80...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6152: Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains International Journal of Molecular Sciences doi: 10.3390/ijms21176152 Authors: Katarzyna Kosznik-Kwaśnicka Karolina Ciemińska Michał Grabski Łukasz Grabowski Marcin Górniak Agata Jurczak-Kurek Grzegorz Węgrzyn Alicja Węgrzyn Molecular and functional characterization of a series of three bacteriophages, vB_SenM-1, vB_SenM-2, and vB_SenS-3, infecting...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6153: The Structure of Clostridioides difficile SecA2 ATPase Exposes Regions Responsible for Differential Target Recognition of the SecA1 and SecA2-Dependent Systems International Journal of Molecular Sciences doi: 10.3390/ijms21176153 Authors: Nataša Lindič Jure Loboda Aleksandra Usenik Robert Vidmar Dušan Turk SecA protein is a major component of the general bacterial secretory system. It is an ATPase that couples nucleotide hydrolysis to protein translocation....
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6150: Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis International Journal of Molecular Sciences doi: 10.3390/ijms21176150 Authors: Kathryn Hally Sebastien Fauteux-Daniel Hind Hamzeh-Cognasse Peter Larsen Fabrice Cognasse While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6151: Hydride Abstraction as the Rate-Limiting Step of the Irreversible Inhibition of Monoamine Oxidase B by Rasagiline and Selegiline: A Computational Empirical Valence Bond Study International Journal of Molecular Sciences doi: 10.3390/ijms21176151 Authors: Tana Tandarić Alja Prah Jernej Stare Janez Mavri Robert Vianello Monoamine oxidases (MAOs) catalyze the degradation of a very broad range of biogenic and dietary amines including many neurotransmitters...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6146: Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress International Journal of Molecular Sciences doi: 10.3390/ijms21176146 Authors: Yuka Eura Toshiyuki Miyata Koichi Kokame Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a quality control system that induces the degradation of ER terminally misfolded proteins. The ERAD system consists of complexes of multiple ER membrane-associated and luminal proteins that function...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6147: Redox Signaling and Regional Heterogeneity of Endothelial Dysfunction in db/db Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176147 Authors: Nada A. Sallam Ismail Laher The variable nature of vascular dysfunction in diabetes is not well understood. We explored the functional adaptation of different arteries in db/db mice in relation to increased severity and duration of diabetes. We compared endothelium-dependent and -independent vasodilation...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6145: Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria International Journal of Molecular Sciences doi: 10.3390/ijms21176145 Authors: Magdalena Stolarska Arleta Glowacka-Sobotta Dariusz T. Mlynarczyk Jolanta Dlugaszewska Tomasz Goslinski Jadwiga Mielcarek Lukasz Sobotta Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6148: A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response to Mycobacterium tuberculosis and Co-Infection with HIV International Journal of Molecular Sciences doi: 10.3390/ijms21176148 Authors: Huy Nguyen Nicky Gazy Vishwanath Venketaraman Mycobacterium tuberculosis (Mtb) is a highly infectious acid-fast bacillus and is known to cause tuberculosis (TB) in humans. It is a leading cause of death from a sole infectious agent, with an estimated...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6142: Bioactive Phenolics and Polyphenols: Current Advances and Future Trends International Journal of Molecular Sciences doi: 10.3390/ijms21176142 Authors: Daniel A. Jacobo-Velázquez Luis Cisneros-Zevallos Phenolic compounds are secondary plant metabolites with remarkable health-promoting properties [...]
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6143: Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression International Journal of Molecular Sciences doi: 10.3390/ijms21176143 Authors: Jichun Chen Shuling Zhang Xingmin Feng Zhijie Wu Wendy Dubois Vishal Thovarai Sonia Ahluwalia Shouguo Gao Jinguo Chen Tyler Peat Shurjo K. Sen Giorgio Trinchieri Neal S. Young Beverly A. Mock Specific-pathogen-free (SPF) mice have improved hematopoietic...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6141: Predicting FOXM1-Mediated Gene Regulation through the Analysis of Genome-Wide FOXM1 Binding Sites in MCF-7, K562, SK-N-SH, GM12878 and ECC-1 Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21176141 Authors: Keunsoo Kang Yoonjung Choi Hoo Hyun Kim Kyung Hyun Yoo Sungryul Yu Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types....
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6144: T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion International Journal of Molecular Sciences doi: 10.3390/ijms21176144 Authors: Freya R. Shepherd James E. McLaren The human body frequently encounters harmful bacterial pathogens and employs immune defense mechanisms designed to counteract such pathogenic assault. In the adaptive immune system, major histocompatibility complex (MHC)-restricted αβ...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6140: Artificial Light at Night Increases Recruitment of New Neurons and Differentially Affects Various Brain Regions in Female Zebra Finches International Journal of Molecular Sciences doi: 10.3390/ijms21176140 Authors: Stan Moaraf Rachel Heiblum Yulia Vistoropsky Monika Okuliarová Michal Zeman Anat Barnea Despite growing evidence that demonstrate adverse effects of artificial light at night (ALAN) on many species, relatively little is known regarding...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6138: Production of Lipopeptide Biosurfactant by a Hydrocarbon-Degrading Antarctic Rhodococcus International Journal of Molecular Sciences doi: 10.3390/ijms21176138 Authors: Syahir Habib Siti Aqlima Ahmad Wan Lutfi Wan Johari Mohd Yunus Abd Shukor Siti Aisyah Alias Jerzy Smykla Nurul Hani Saruni Nur Syafiqah Abdul Razak Nur Adeela Yasid Rhodococci are renowned for their great metabolic repertoire partly because of their numerous putative pathways...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6139: Novel Insights into the Regulatory Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 in Oxidative Stress and Inflammation of Human Fetal Membranes International Journal of Molecular Sciences doi: 10.3390/ijms21176139 Authors: Ramkumar Menon Morgan R Peltier Fetal membrane dysfunction in response to oxidative stress (OS) is associated with adverse pregnancy outcomes. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is one of the regulators of innate OS...
Wed Aug 26, 2020 03:00
IJMS, Vol. 21, Pages 6137: Photosystem Disorder Could be the Key Cause for the Formation of Albino Leaf Phenotype in Pecan International Journal of Molecular Sciences doi: 10.3390/ijms21176137 Authors: Ji-Yu Zhang Tao Wang Zhan-Hui Jia Zhong-Ren Guo Yong-Zhi Liu Gang Wang Pecan is one of the most famous nut species in the world. The phenotype of mutants with albino leaves was found in the process of seeding pecan, providing ideal material for the study of the molecular...
Wed Aug 26, 2020 03:00
Toxics, Vol. 8, Pages 63: Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data Toxics doi: 10.3390/toxics8030063 Authors: Aleksandra Buha Danijela Đukić-Ćosić Marijana Ćurčić Zorica Bulat Biljana Antonijević Jean-Marc Moulis Marina Goumenou David Wallace Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation...
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JCM, Vol. 9, Pages 2772: L-Arginine Modulates Neonatal Leukocyte Recruitment in a Gestational Age-Dependent Manner Journal of Clinical Medicine doi: 10.3390/jcm9092772 Authors: Raphaela Fitterer Trim Lajqi Simon Alexander Kranig Maylis Braun Nicole Theissig Navina Kuss Johannes Pöschl David Frommhold Hannes Hudalla (1) Background: L-arginine is a complex modulator of immune functions, and its levels are known to decrease under septic conditions. L-arginine may...
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JCM, Vol. 9, Pages 2771: Increased Elastin Degradation in Pseudoxanthoma Elasticum Is Associated with Peripheral Arterial Disease Independent of Calcification Journal of Clinical Medicine doi: 10.3390/jcm9092771 Authors: Jonas W. Bartstra Wilko Spiering Jody M. W. van den Ouweland Willem P. T. M. Mali Rob Janssen Pim A. de Jong Pseudoxanthoma elasticum (PXE) results in extensive fragmentation and calcification of elastin fibers in the peripheral arteries, which results...
Wed Aug 26, 2020 03:00
JCM, Vol. 9, Pages 2769: Early Outcomes of Percutaneous Pulmonary Valve Implantation with Pulsta and Melody Valves: The First Report from Korea Journal of Clinical Medicine doi: 10.3390/jcm9092769 Authors: Kim Jung Jung Shin Eun Kim Choi Percutaneous pulmonary valve implantation (PPVI) is used to treat pulmonary stenosis (PS) or pulmonary regurgitation (PR). We described our experience with PPVI, specifically valve-in-valve transcatheter pulmonary valve replacement...
Wed Aug 26, 2020 03:00
JCM, Vol. 9, Pages 2768: Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis Journal of Clinical Medicine doi: 10.3390/jcm9092768 Authors: Sade Wainstock Sheiner Pariente Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity...
Wed Aug 26, 2020 03:00
JCM, Vol. 9, Pages 2770: Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9092770 Authors: Charles Tharp Luisa Mestroni Matthew Taylor Titin is the largest human protein and an essential component of the cardiac sarcomere. With multiple immunoglobulin(Ig)-like domains that serve as molecular springs, titin contributes significantly to the passive...
Wed Aug 26, 2020 03:00
JCM, Vol. 9, Pages 2766: Predictive Factors Associated with Complications after Laparoscopic Distal Pancreatectomy Journal of Clinical Medicine doi: 10.3390/jcm9092766 Authors: Ki Byung Song Sarang Hong Hwa Jung Kim Yejong Park Jaewoo Kwon Woohyung Lee Eunsung Jun Jae Hoon Lee Dae Wook Hwang Song Cheol Kim Although laparoscopic distal pancreatectomy (LDP) has become more popular, the postoperative complication rate remains high. We sought to identify the risk...
Wed Aug 26, 2020 03:00
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