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Δευτέρα 24 Απριλίου 2017

Stereoselective synthesis of [gamma]-hydroxy-[small alpha]-amino acids through Aldolase-Transaminase recycling cascades

Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C7CC00742F, Communication
Christine Helaine, Egon Heuson, Moussa Ndiaye, Lea Gourbeyre, Marielle Lemaire, Virgil Helaine, Franck Charmantray, Jean-Louis Petit, Marcel Salanoubat, Veronique de Berardinis, T Gefflaut
Efficient bienzymatic cascades combining aldolases and [small alpha]-transaminases were designed for the synthesis of [gamma]-hydroxy-[small alpha]-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination....
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