Antithrombotic therapies in digit replantation with papaverine administration: A prospective, observational study.

Background: The primary objective of this study was to investigate whether the application of antithrombotic therapies affects the success rate of digit replantation. Methods: Total 477 digits of 319 patients who received dextran with low molecular weight heparin (dextran-LMWH), dextran with prostaglandin E1 (dextran-PGE1), or no antithrombotic therapy after replantation of complete amputated digits from 1 January 2012 to 1 January 2016 were included in this study. Papaverine were given by intramuscular injection to all patients with 90mg/day postoperatively. Results: There was no significant difference in all potential risk factors including age, smoking, Tamai's level of amputation, causes of injury and warm ischemia time among groups. The survival rate of digits from patients who received dextran-LMWH, dextran-PGE1, or no antithrombotic therapy had no significant difference. Conclusions: Antithrombotic therapies showed no significant benefit for digital replantation in patients receiving papaverine. (C)2017American Society of Plastic Surgeons

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