Metallo-{beta}-lactamases (DIM-1, NDM-1, VIM-2) and a 16S rRNA methyltransferase (RmtB4, RmtF2) producing Pseudomonas aeruginosa in Nepal [PublishAheadOfPrint]

A total of 11 multidrug-resistant Pseudomonas aeruginosa clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1_, NDM-1 and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with RmtF. To our knowledge, this is the first report describing carbapenemase- and 16S rRNA methyltransferase-co-producing P. aeruginosa clinical isolates in Nepal.

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