Expansion of cytotoxic CD56bright NK cells during T cell deficiency after allogeneic hematopoietic stem cell transplantation

Publication date: Available online 1 August 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Gertjan Lugthart, Marieke Goedhart, Merle M. van Leeuwen, Janine E. Melsen, Cornelia M. Jol-van der Zijde, Carly Vervat, Monique M. van Ostaijen-ten Dam, Anja M. Jansen-Hoogendijk, Maarten J.D. van Tol, Arjan C. Lankester, Marco W. Schilham

Teaser

We describe a compensatory expansion of activated cytotoxic CD56^bright NK cells during T-cell deficiency after hematopoietic stem cell transplantation. This mimics the situation in severe inborn T-cell deficiencies and unmasks the functional and phenotypic versatility of NK cells.


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