Using multi-omics methods to understand dermatomyositis/ polymyositis

Publication date: Available online 1 August 2017
Source:Autoimmunity Reviews
Author(s): Siming Gao, Hui Luo, Huali Zhang, Xiaoxia Zuo, Li Wang, Honglin Zhu
Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics. This integrated analysis of multi-omics profiling will provide useful insights into DM/PM pathogenesis and recommendations for therapeutic targets and biomarkers development.



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