Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Drivers of Iclaprim [PublishAheadOfPrint]

The neutropenic, murine thigh infection model was used to define the PK/PD index linked to efficacy of iclaprim against S. aureus ATCC 29213 and S. pneumoniae ATCC 10813. The 24h AUC/MIC index was most closely linked to efficacy for S. aureus (R²=0.65), while both the 24h AUC/MIC and the %T>MIC were both strongly associated with effect (R²=0.86 for both parameters) for S. pneumoniae.

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