Pharmacokinetics of tedizolid in obese patient after bariatric surgery: a case report [PublishAheadOfPrint]

An obese woman was treated orally by tedizolid 200 mg once daily for a pseudoarthrosis, 10 years after a Roux-en-Y bypass surgery.

Total plasma peak concentration was 2.12 mg/L, 3h after intake and AUC_0-24h was 28.3 mg/L*h. The AUC_0-24h/MIC ratio for unbound concentrations and for sensible Staphylococcus and Streptococcus strains was at least 10.8, higher than a targeted ratio of 3.

These results support the use of tedizolid without adjustment after a bariatric surgery.

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