Importance of Site of Infection and Antibiotic Selection in the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Sepsis [PublishAheadOfPrint]

In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04-1.39 P=0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71-0.90; P=0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR [aRR], 1.72; 95% CI, 1.03-2.85; P=0.037), consistent across multiple sites of infection.

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