Trans-Cinnamic acid (CA) is a natural organic compound. Using amoebicidal assays, for the first time we showed that CA affected viability of protist pathogen, Acanthamoeba castellanii. Conjugation with gold nanoparticles (AuNPs) enhanced antiamoebic effects of CA. Cinnamic acid coated gold nanoparticles (CA-AuNPs) also exhibited significant excystation and encystation activity as compared to CA and AuNPs alone. Pre-treatment of amoebae with CA-AuNPs inhibited A. castellanii-mediated host cell cytotoxicity. Moreover, CA-AuNPs exhibited potent effects against methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1 as well as protected host cells against bacterial-mediated host cell death.
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